Southeast Missouri Vacations from ￥235,864

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The Latest Southeast Missouri Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
per person
May 12 - May 17
found 20 hours ago
Roundtrip non-stop flight included
Tokyo (TYO) to St. Louis (STL)
9/10 Wonderful! (1,464 reviews)
Hotel staff was helpful and friendly.

Reviewed on Apr 1, 2025

Barsala At Ballpark Heights

Barsala At Ballpark Heights

4 out of 5
Downtown St. Louis
per person
May 12 - May 17
found 19 hours ago
Roundtrip non-stop flight included
Tokyo (TYO) to St. Louis (STL)
6.4/10 (5 reviews)
Wi fi not working, it took a very long time to hear back from anyone after multiple times contacting. No coffee cups.

Reviewed on Mar 28, 2025

Barsala At 275 On The Park - Congress Apartments

Barsala At 275 On The Park - Congress Apartments

4 out of 5
DeBaliviere Place
per person
May 12 - May 17
found 19 hours ago
Roundtrip non-stop flight included
Tokyo (TYO) to St. Louis (STL)
5/10 (2 reviews)
Pros: The apartment was easy to access within walking distance of the metro. The shower had good hot water. The bed was very comfortable. There were complementary snacks provided, and there is a coffee shop connected to the building. Cons: The apartment did not provide bath towels, so we were unable to shower for the first half of our stay. When we reached out to the management, he never responded. His hours were M-F 8am-5pm, and our check-in time was 5pm on Friday to stay through Sunday. By the time we realized there were no towels, he was off work for the weekend and never helped. Additionally, the password for the WiFi was incorrect on the router, and we could not use WiFi for the weekend.

Reviewed on Mar 9, 2025

The Cheshire

The Cheshire

4 out of 5
per person
May 12 - May 17
found 20 hours ago
Roundtrip non-stop flight included
Tokyo (TYO) to St. Louis (STL)
8.4/10 Very Good! (1,003 reviews)
The property has a lot of charm.

Reviewed on Mar 27, 2025

The West End

The West End

2 out of 5
Central West End
per person
May 12 - May 17
found 20 hours ago
Roundtrip non-stop flight included
Tokyo (TYO) to St. Louis (STL)
8.2/10 Very Good! (171 reviews)
The public shared kitchen is very convenient. However, the lack of windows that open made the room feel a bit stuffy, which was less comfortable.

Reviewed on Mar 30, 2025

Find the Best Southeast Missouri Vacation Packages

Southeast Missouri Hotel Deals

The Riverview
The Riverview
3.5 out of 5
777 Main St, Cape Girardeau, MO
The price is ￥13,085 per night from Apr 20 to Apr 21
￥13,085
￥14,761 total
includes taxes & fees
Apr 20 - Apr 21
9.2/10 Wonderful! (200 reviews)
Hotel Great, Casino so Tight!
"Love this modern, clean hotel. Must admit the casino has never been kind to me."

Reviewed on Mar 29, 2025

The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is ￥14,163 per night from Apr 6 to Apr 7
￥14,163
￥15,977 total
includes taxes & fees
Apr 6 - Apr 7
9.4/10 Exceptional! (1,000 reviews)
"Na"

Reviewed on Apr 1, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
Fully refundableReserve now, pay when you stay
The price is ￥8,034 per night from Apr 13 to Apr 14
￥8,034
￥9,147 total
includes taxes & fees
Apr 13 - Apr 14
8/10 Very Good! (895 reviews)
Good location
"Nice hotel. Good size room.Staff was very polite. Plenty of places to find a drink and meal near by. The hotel fit our needs. Good location."

Reviewed on Mar 31, 2025

Baymont Inn and Suites by Wyndham Farmington, MO
See all 554 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Southeast Missouri vacation package cost?
Cross off another part of the world with our Southeast Missouri vacation packages, which start from just ￥235,864. Select the flights and hotels that match your travel plans. Then, add on one or two tours or experiences for an unforgettable adventure.
How do I get a cheap travel package to Southeast Missouri?
Browse and book everything in the one place with our Southeast Missouri vacation packages. You’ll find deals on flights, hotels, tours and more that’ll keep your pocket happy and your adventurous spirit alive. And, with more than 550 partner airlines and 1,000,000 hotels around the world to select from, you’ll have endless opportunities to mix and match your own way.
What are the top hotels in Southeast Missouri?
When it comes to properties in Cape Girardeau, Drury Plaza Hotel Cape Girardeau Conference Center and Pear Tree Inn Cape Girardeau West are a couple of favorites. If you’re considering heading to Ste Genevieve, City Place St. Louis Downtown and The Branson Hillside Hotel are waiting to welcome you.
How far in advance should I book my Southeast Missouri vacation?
It’s tricky picking the perfect time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to a year in advance. If you can’t book ahead, don’t worry. Cheap prices appear from time to time within a few weeks of departure dates.
What does an Expedia Southeast Missouri travel package include?
From hotels and flights to car rentals, Expedia can help you craft a Southeast Missouri package that fits you. Vacationing for a week or two? Look into a rental car, hotel and flight bundle. If you’re taking a quick break, a hotel and airfare deal may suit you better. Experiences can also be added once you’ve made your booking. Our packages make it a breeze to plan and save.
What should I know before booking a Southeast Missouri travel package?
When you book your flights, hotels and car rentals together, you’ll pick up terrific discounts. Whether you’re planning a beach escape in a villa or prefer to stay in a comfortable hotel in the city, Expedia will help make it happen.
Can I choose my airline with a Southeast Missouri Expedia vacation package?
You can, and with over 550 airlines to pick from around the world, you’re spoiled for choice. Have a look through the available options and see which airline best suits your budget and needs.
If I'm not able to travel, can I cancel my Southeast Missouri vacation package?
Because we understand life is full of surprises, the answer is yes. To learn more, head to our Customer Service Portal. But generally speaking, if you’ve booked your Southeast Missouri vacation package in the last 24 hours, you may be able to cancel or change it for no charge. Your hotel, airline or car rental company may charge a fee if your booking is older than that.

Discover the most popular places to visit in Southeast Missouri

Southeast Missouri State University

4.5/5(76 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

Southeast Missouri State University

Alley Spring & Mill

4.5/5(4 reviews)

Learn about the local history of Eminence with a stop at Alley Spring & Mill. While you're in the area, stroll along the riverfront.

Alley Spring & Mill

What to do in Southeast Missouri

Castle Entrance

History Tour of Pythian Castle in Springfield Missouri

￥1,858
per adult
80% of travellers recommend
History Tour of Pythian Castle in Springfield Missouri
Pythian Castle

Night Ghost Tour of Pythian Castle in Springfield Missouri

￥2,971
per adult
100% of travellers recommend
Night Ghost Tour of Pythian Castle in Springfield Missouri
Ozark Craft Beverage - Brewery Tour

Ozark Craft Beverage - Brewery Tour

￥15,246
per adult
Ozark Craft Beverage - Brewery Tour
See all activities in Southeast Missouri
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.