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Find hotels in South Main, Houston from ￥6,481

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Check prices for these dates

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Feb 8 - Feb 9
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Feb 9 - Feb 10
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Feb 14 - Feb 16
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Feb 21 - Feb 23

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Discover 6,387 South Main hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Comfort Suites near Texas Medical Center - NRG Stadium
Lobby

Comfort Suites near Texas Medical Center - NRG Stadium

2.5 star property
8.6 out of 10, Excellent, (763)
"Close by the stadium."
The price is ￥14,470
￥16,929 total
includes taxes & fees
Feb 9 - Feb 10
Comfort Suites near Texas Medical Center - NRG Stadium
Wyndham Houston near NRG Park/Medical Center
View from property

Wyndham Houston near NRG Park/Medical Center

3.5 star property
7.4 out of 10, Good, (1002)
"Its in a great location, great staff. "
The price is ￥15,722
￥18,394 total
includes taxes & fees
Feb 13 - Feb 14
Wyndham Houston near NRG Park/Medical Center
Candlewood Suites Houston Medical Center by IHG
Exterior

Candlewood Suites Houston Medical Center by IHG

2.5 star property
7.6 out of 10, Good, (729)
"Good stay"
The price is ￥11,810
￥13,818 total
includes taxes & fees
Feb 16 - Feb 17
Candlewood Suites Houston Medical Center by IHG
Wingate Houston near NRG Park/Medical Center
Room, 2 Double Beds, Non Smoking | Desk, laptop workspace, blackout drapes, iron/ironing board

Wingate Houston near NRG Park/Medical Center

3.0 star property
6.8 out of 10, (811)
"Front desk Ms. Mehrsa was very helpful. I had an issue with desk chair in my room and she took care of it right away. Also the lady working the breakfast area was very helpful and nice."
The price is ￥13,454
￥15,741 total
includes taxes & fees
Feb 15 - Feb 16
Wingate Houston near NRG Park/Medical Center
Quality Inn & Suites NRG Park - Medical Center
Hypo-allergenic bedding, in-room safe, individually decorated

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
6.6 out of 10, (1001)
"-The door to enter the building was broken. -You can hear some noise from rooms upstairs. -every thing else was very good. "
The price is ￥10,431
￥12,204 total
includes taxes & fees
Feb 13 - Feb 14
Quality Inn & Suites NRG Park - Medical Center
OYO Hotel Houston Tx Medical Center Nrg Stadium
Lobby

OYO Hotel Houston Tx Medical Center Nrg Stadium

2.5 star property
3.8 out of 10, (412)
"I did not get to stay. I booked threw expedia. Arrived to be sentvaway because the motel was already at full capacity"
The price is ￥6,481
￥8,490 total
includes taxes & fees
Feb 24 - Feb 25
OYO Hotel Houston Tx Medical Center Nrg Stadium
La Quinta Inn & Suites by Wyndham Deer Park
Exterior

La Quinta Inn & Suites by Wyndham Deer Park

2.5 star property
8.4 out of 10, Very Good, (366)
"Only thing that could use some improvement is the breakfast food options. "
The price is ￥12,718
￥14,880 total
includes taxes & fees
Mar 4 - Mar 5
La Quinta Inn & Suites by Wyndham Deer Park
La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd
Pillowtop beds, desk, iron/ironing board, free WiFi

La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd

3.5 star property
9.2 out of 10, Wonderful, (888)
"Aplus in all categories "
The price is ￥10,305
￥11,851 total
includes taxes & fees
Feb 23 - Feb 24
La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd
Sonesta Simply Suites Houston – NASA Clear Lake
Fridge, microwave, stovetop, dishwasher

Sonesta Simply Suites Houston – NASA Clear Lake

2.5 star property
8.2 out of 10, Very Good, (830)
"All of the above "
The price is ￥9,236
￥10,806 total
includes taxes & fees
Mar 9 - Mar 10
Sonesta Simply Suites Houston – NASA Clear Lake
SureStay Hotel by Best Western Deer Park
In-room safe, individually furnished, desk, laptop workspace

SureStay Hotel by Best Western Deer Park

2.5 star property
8.4 out of 10, Very Good, (199)
"Huge room, nice staff "
The price is ￥10,478
￥12,260 total
includes taxes & fees
Feb 17 - Feb 18
SureStay Hotel by Best Western Deer Park
stayAPT Suites Houston NASA Clear Lake
Exterior

stayAPT Suites Houston NASA Clear Lake

2.5 star property
9.4 out of 10, Exceptional, (262)
"This place is great! Love the apartment style hotel. The Mo is super friendly and very good at her job. I will stay again! It’s clean and comfortable!"
The price is ￥15,555
￥18,200 total
includes taxes & fees
Feb 10 - Feb 11
stayAPT Suites Houston NASA Clear Lake
La Quinta Inn & Suites by Wyndham Houston/Clear Lake-NASA
Suite, 2 Queen Beds, Non Smoking | Premium bedding, desk, iron/ironing board, free cribs/infant beds

La Quinta Inn & Suites by Wyndham Houston/Clear Lake-NASA

2.5 star property
7.8 out of 10, Good, (1002)
"Very clean and excellent room"
The price is ￥10,939
￥12,799 total
includes taxes & fees
Mar 9 - Mar 10
La Quinta Inn & Suites by Wyndham Houston/Clear Lake-NASA
Best Western Webster Hotel, Nasa
Seasonal outdoor pool, pool umbrellas, sun loungers

Best Western Webster Hotel, Nasa

2.5 star property
7.6 out of 10, Good, (1000)
"My stay was from a unfortunate home issue. The Whole Staff was so understanding & accommodating. The young man at my arrival, because a home plumbing issue was so understanding & concern with my comfort. The clerk Angela & young lady that was at front desk 2/1/2/25 was special in making sure my son & I were ok, in our rechecks. Housekeepers were spot on. Thank you, Best Western Team for making Our Household Dilemma being soothed. Kudos, Best Western Webster,Texas Staff!"
The price is ￥10,067
￥11,778 total
includes taxes & fees
Feb 23 - Feb 24
Best Western Webster Hotel, Nasa
La Quinta Inn & Suites by Wyndham Houston Channelview
Exterior

La Quinta Inn & Suites by Wyndham Houston Channelview

3.5 star property
8.6 out of 10, Excellent, (684)
"Great customer service, fast check in, very secure and felt safe. "
The price is ￥12,416
￥14,527 total
includes taxes & fees
Feb 23 - Feb 24
La Quinta Inn & Suites by Wyndham Houston Channelview
Holiday Inn Express & Suites Houston East - Beltway 8 by IHG
Exterior

Holiday Inn Express & Suites Houston East - Beltway 8 by IHG

2.5 star property
8.4 out of 10, Very Good, (349)
"Really nice piece "
The price is ￥12,245
￥14,326 total
includes taxes & fees
Feb 23 - Feb 24
Holiday Inn Express & Suites Houston East - Beltway 8 by IHG
Palace Inn Blue Houston East Beltway 8
Reception

Palace Inn Blue Houston East Beltway 8

2.5 star property
9.0 out of 10, Wonderful, (243)
"N/_"
The price is ￥9,731
￥11,191 total
includes taxes & fees
Mar 9 - Mar 10
Palace Inn Blue Houston East Beltway 8
La Quinta Inn & Suites by Wyndham Pasadena North
Lobby

La Quinta Inn & Suites by Wyndham Pasadena North

2.5 star property
7.8 out of 10, Good, (530)
"Ok"
The price is ￥10,763
￥12,592 total
includes taxes & fees
Mar 11 - Mar 12
La Quinta Inn & Suites by Wyndham Pasadena North
Bluestar Inn
Individually furnished, desk, iron/ironing board, free WiFi

Bluestar Inn

2.5 star property
9.0 out of 10, Wonderful, (195)
"Amazing i love it i will be back soon"
The price is ￥11,035
￥12,911 total
includes taxes & fees
Feb 16 - Feb 17
Bluestar Inn
Best Western Plus Heritage Inn
Reception

Best Western Plus Heritage Inn

3.0 star property
8.0 out of 10, Very Good, (586)
"Enjoyed my stay. "
The price is ￥11,838
￥13,850 total
includes taxes & fees
Feb 14 - Feb 15
Best Western Plus Heritage Inn
Sonesta Essential Houston Hobby Airport
Lobby

Sonesta Essential Houston Hobby Airport

2.5 star property
6.6 out of 10, (1001)
"Good place to stay. "
The price is ￥7,593
￥9,769 total
includes taxes & fees
Feb 18 - Feb 19
Sonesta Essential Houston Hobby Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

What is South Main like?

You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on Expedia customer reviews, Comfort Suites near Texas Medical Center - NRG Stadium is the highest ranked property in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighborhood include Candlewood Suites Houston Medical Center by IHG and Wyndham Houston near NRG Park/Medical Center.

How many hotels will I be able to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 66 South Main hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.

Where can I learn more about changing or cancelling my trip to South Main?

For more details about changing or cancelling your trip to South Main, head over to our customer service page.

What can I see and do in this Houston neighborhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.