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Find hotels in South Main, Houston from ￥12,718

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Discover 6,192 South Main hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Club Quarters Hotel Downtown, Houston
Exterior

Club Quarters Hotel Downtown, Houston

4.0 star property
8.2 out of 10, Very Good, (3130)
"Great location. Close to the concert we went to "
The price is ￥14,116
￥16,516 total
includes taxes & fees
Dec 24 - Dec 25
Club Quarters Hotel Downtown, Houston
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Exterior detail

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4.0 star property
8.0 out of 10, Very Good, (1588)
"Great"
The price is ￥15,683
￥18,478 total
includes taxes & fees
Dec 25 - Dec 26
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
The Whitehall Houston
City view from property

The Whitehall Houston

4.0 star property
8.4 out of 10, Very Good, (1088)
"I loved the late checkout and the staff were super helpful! Valet provided fast and awesome customer service. Very convenient location as well, highly recommended!"
The price is ￥17,707
￥20,716 total
includes taxes & fees
Dec 2 - Dec 3
The Whitehall Houston
Blossom Hotel Houston
City view

Blossom Hotel Houston

4.0 star property
9.2 out of 10, Wonderful, (2872)
"It was a One night only for my GF birthday, and we enjoyed the luxury. Pleasant stay. The aroma of the Hotel smells so nice. I had to Google your Body Wash for purchase because the scent is Oh my God!!!! "
The price is ￥20,581
￥24,081 total
includes taxes & fees
Dec 1 - Dec 2
Blossom Hotel Houston
Holiday Inn Houston Downtown, an IHG Hotel
Property amenity

Holiday Inn Houston Downtown, an IHG Hotel

3.0 star property
8.6 out of 10, Excellent, (1006)
"The hotel was great.It was clean,friendly staff.The br"
The price is ￥13,682
￥18,725 total
includes taxes & fees
Dec 22 - Dec 23
Holiday Inn Houston Downtown, an IHG Hotel
Marriott Marquis Houston
2 outdoor pools, open 6:00 AM to 10:00 PM, cabanas (surcharge)

Marriott Marquis Houston

4.0 star property
8.8 out of 10, Excellent, (1017)
"Stuff"
The price is ￥34,671
￥45,852 total
includes taxes & fees
Dec 23 - Dec 24
Marriott Marquis Houston
Hilton Americas-Houston
Exterior

Hilton Americas-Houston

4.0 star property
9.2 out of 10, Wonderful, (1132)
"The towels had a couple of stains on them. I felt like their room could’ve been cleaned a little bit better but otherwise very pleasant."
The price is ￥26,043
￥30,835 total
includes taxes & fees
Dec 22 - Dec 23
Hilton Americas-Houston
Hyatt Regency Houston Downtown
City view

Hyatt Regency Houston Downtown

4.0 star property
9.2 out of 10, Wonderful, (1042)
"Good "
The price is ￥23,542
￥28,496 total
includes taxes & fees
Dec 19 - Dec 20
Hyatt Regency Houston Downtown
C. Baldwin, Curio Collection by Hilton
Outdoor banquet area

C. Baldwin, Curio Collection by Hilton

4.0 star property
8.4 out of 10, Very Good, (925)
"I loved this property and the surrounding neighborhood. The decor and artwork in the lobby were top notch. I was very happy with the comfort of the bed and the staff was attentive. I'd definitely coming back."
The price is ￥21,998
￥29,840 total
includes taxes & fees
Nov 26 - Nov 27
C. Baldwin, Curio Collection by Hilton
Hyatt Place Houston Medical Center
Lobby

Hyatt Place Houston Medical Center

3.0 star property
9.0 out of 10, Wonderful, (1172)
"Na"
The price is ￥17,970
￥21,138 total
includes taxes & fees
Nov 26 - Nov 27
Hyatt Place Houston Medical Center
Rusk House Serviced Apartments
Check-in/check-out kiosk

Rusk House Serviced Apartments

4.5 star property
9.2 out of 10, Wonderful, (84)
"Would definitely stay again! The staff was accommodating, check in process was seamless, and the room was great. There were a couple of small things that I did not like, but the good outweighed the bad tenfold. Next time I’m in Houston, I’m staying here!"
The price is ￥21,669
￥25,353 total
includes taxes & fees
Nov 30 - Dec 1
Rusk House Serviced Apartments
Hyatt Place Houston Downtown
Lobby sitting area

Hyatt Place Houston Downtown

3.0 star property
9.0 out of 10, Wonderful, (1410)
"Azur and Nay were amazing. They were very helpful. Azur went the extra mile To make sure we were accommodated and comfortable. He had an amazing presence and energy. May remembered me from questions I asked her on the phone when I checked in. That says alot about the attention to detail. Great stay. Room was very clean. Only issue we had was the hallway by the ice machine smelled like urine. Other than that I give the stay 5 stars! "
The price is ￥20,392
￥24,256 total
includes taxes & fees
Nov 26 - Nov 27
Hyatt Place Houston Downtown
Cambria Hotel Houston Downtown Convention Center
Lobby

Cambria Hotel Houston Downtown Convention Center

3.0 star property
8.8 out of 10, Excellent, (1437)
"Great clean convenient "
The price is ￥16,899
￥19,771 total
includes taxes & fees
Dec 22 - Dec 23
Cambria Hotel Houston Downtown Convention Center
Le Meridien Houston Downtown
Rooftop terrace

Le Meridien Houston Downtown

4.0 star property
8.6 out of 10, Excellent, (867)
"Decent hotel with excellent staff. Bed wasn’t very comfortable, but otherwise a good stay. "
The price is ￥23,403
￥27,380 total
includes taxes & fees
Nov 26 - Nov 27
Le Meridien Houston Downtown
Crowne Plaza Houston Med Ctr-Galleria Area, an IHG Hotel
Standard Room, 2 Queen Beds | Premium bedding, Tempur-Pedic beds, desk, laptop workspace

Crowne Plaza Houston Med Ctr-Galleria Area, an IHG Hotel

3.5 star property
7.4 out of 10, Good, (1003)
"Nice, updated, enjoyed my stay "
The price is ￥12,718
￥14,881 total
includes taxes & fees
Nov 26 - Nov 27
Crowne Plaza Houston Med Ctr-Galleria Area, an IHG Hotel
The Post Oak Hotel at Uptown Houston
Outdoor pool, cabanas (surcharge), pool umbrellas

The Post Oak Hotel at Uptown Houston

5.0 star property
9.6 out of 10, Exceptional, (674)
"Amazing service, great quality "
The price is ￥86,367
￥101,049 total
includes taxes & fees
Dec 8 - Dec 9
The Post Oak Hotel at Uptown Houston
Moxy Houston Downtown
Front of property - evening/night

Moxy Houston Downtown

3.0 star property
9.0 out of 10, Wonderful, (263)
"I really liked the hotel. Great for young professionals. Bartenders were awesome with good recommendations for nightlife. Would definitely stay there again"
The price is ￥12,754
￥15,232 total
includes taxes & fees
Nov 27 - Nov 28
Moxy Houston Downtown
The Chifley Houston, Tapestry Collection by Hilton
Lobby

The Chifley Houston, Tapestry Collection by Hilton

4.0 star property
8.8 out of 10, Excellent, (1017)
"Close to shopping mall and nearby stores "
The price is ￥23,024
￥26,939 total
includes taxes & fees
Nov 27 - Nov 28
The Chifley Houston, Tapestry Collection by Hilton
The Royal Sonesta Houston Galleria
Exterior

The Royal Sonesta Houston Galleria

4.0 star property
8.2 out of 10, Very Good, (1017)
"Stay was great! Carpet needs replacing in the rooms."
The price is ￥23,575
￥31,567 total
includes taxes & fees
Dec 13 - Dec 14
The Royal Sonesta Houston Galleria
InterContinental Houston, an IHG Hotel
International cuisine

InterContinental Houston, an IHG Hotel

4.0 star property
9.2 out of 10, Wonderful, (1013)
"Clean and comfortable. Evening music in the lobby was a great way to end the day. "
The price is ￥21,711
￥27,724 total
includes taxes & fees
Nov 28 - Nov 29
InterContinental Houston, an IHG Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

What is South Main like?

You'll be sure to have fun visiting Houston's South Main neighborhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on Expedia customer reviews, Comfort Suites near Texas Medical Center - NRG Stadium is the highest ranked property in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighborhood include Candlewood Suites Houston Medical Center, an IHG Hotel and Wyndham Houston near NRG Park/Medical Center.

How many hotels will I be able to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 68 South Main hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available in South Main.

Where can I learn more about changing or cancelling my trip to South Main?

For more details about changing or cancelling your trip to South Main, head over to our customer service page.

What can I see and do in this Houston neighborhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, be sure to visit other sights like NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.